6 Crc mutants develop a range of developmental defects that affect the neural tube, body wall, and branching organs such as the lung. 3, 4 Mutations in Scrib are found in the mouse mutant circletail ( Crc). 4 Related roles in neoplasia have been identified in mammals, 5 with mammalian Scrib shown to play roles in a variety of cellular processes including the establishment of apicalвЂ“basal and planar cell polarity, migration, proliferation, differentiation, and vesicle trafficking. 3, 4 In Drosophila, scribble plays roles in maintaining apicalвЂ“basal polarity and its loss is associated with tissue overgrowth suggesting roles in cell proliferation and/or neoplasia. Scrib is a large scaffolding protein that forms complexes with other proteins at the cell junctions of expressing cells. The relationship between abnormal development of the myocardium and adult heart disease, however, remains unclear. Nevertheless, minor defects may be compatible with survival in the postnatal period. 2 Anything more than minor abnormalities in the formation of the ventricular myocardium during embryonic life are likely to result in death of the embryo. 1 Abnormalities in the arrangement of cardiomyocytes within the myocardium are associated with a range of adult diseases, including cardiomyopathy, hypertrophy, and heart failure.

Maturation of ventricular cardiomyocytes is poorly understood.

Photoshop creative collection scrib